Spontaneous reactivation and aging kinetics of acetylcholinesterase inhibited by dichlorvos and diazinon
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چکیده
منابع مشابه
Effect of Gallic Acid on Reactivation of Acetylcholinesterase and Butyrylcholinesterase Inhibited by Diazinon in Vitro and in Vivo
Background and purpose: Diazinon is an organophosphate insecticide that binds to the acetylcholinesterase enzyme after metabolization causing its inactivation. Galic acid is a polyphenolic compound with nucleophilic properties. The aim of this study was to investigate the effects of gallic acid on reactivation of acetylcholine and butyrylcholinesterase inhibited by diazinon in mice and human se...
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Owing to the threat of organophosphate exposures, not only to pesticides but also to nerve agents, it is very important to know the whole process of organophosphates-inhibited acetylcholinesterase (AChE, EC 3.1.1.7) reactivation. Although current antidotes against organophosphorus intoxications consist also of prophylactics, AChE reactivators are still needed especially in the case of intoxicat...
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In a previous paper (1) it was shown that the inhibition of acetylcholinesterase caused by tetraethyl pyrophosphate, while irreversible by dialysis or dilution, could be reversed rapidly by reaction with hydroxylamine or choline and very slowly by reaction with water. A theory of the mechanism of inhibition by phosphate esters (tetraalkyl pyrophosphates, dialkyl halophosphates, dialkyl p-nitrop...
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In a previous paper (1) it was shown that the inhibition of acetylcholinesterase caused by tetraethyl pyrophosphate, while irreversible by dialysis or dilution, could be reversed rapidly by reaction with hydroxylamine or choline and very slowly by reaction with water. A theory of the mechanism of inhibition by phosphate esters (tetraalkyl pyrophosphates, dialkyl halophosphates, dialkyl p-nitrop...
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ژورنال
عنوان ژورنال: The Journal of Toxicological Sciences
سال: 2011
ISSN: 0388-1350,1880-3989
DOI: 10.2131/jts.36.237